MC1568-DataSheet-MedChemExpress
摘要:Inhibitors,Agonists,ScreeningLibrarieswww.MedChemExpress.comDataSheetProductName:MC1568Cat.No.:HY-16914CASNo.:852475-26-4MolecularFormula:C17H15FN2O3MolecularWeight:314.31Target:HDAC;HDACPathway:Epigenetics;CellCycle/DNADamageSolubility:DMSO:18.5mg/mLBIOLOGICALACTIVITY: MC1568isaselectiveclassII(IIa)histonedeacetylas(HDACII)inhibitorwithanIC50of220nM.IC50&Target:IC50:220nM(HDACII)[1]InVitro:MC1568arrestsmyogenesisbydecreasingmyocyteenhancerfactor2D(MEF2D)expression,bystabilizingtheHDAC4–HDAC3–MEF2Dcomplex,andparadoxically,byinhibitingdifferentiation–inducedMEF2Dacetylation[2].MC1568andMC1575inhibitsIL–8levelsandcellproliferationineitherunstimulatedorPMA–stimulatedmelanomacells.Th
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