阿维鲁单抗作用机制---Medchemexpress---MCE中国

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摘要:•AvelumabInhibitorsProductData SheetAgonistsHY-108730CASNo.:1537032-82-8作⽤靶点:PD-1/PD-L1作⽤通路:Immunology/Inflammation储存⽅式:Pureform-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month•Cat.No.:ScreeningLibrariesBIOLOGICALACTIVITY⽣物活性Avelumab是⼀个⼈IgG1抗PD-L1单克隆抗体，具有潜在的抗体依赖性细胞介导的细胞毒性作⽤。IC₅₀&TargetPD-1/PD-L1[1]体外研究AvelumabisafullyhumanIgG1anti-PD-L1monoclonalantibodywithpotentialantibody-dependentcell-mediatedcytotoxicityproperty.AvelumabincreasesNK-celllysis3.1-fold(P=0.01)inJHC7cellsrelativetoisotypecontrol.WhenthecellsaretreatedwithIFN-γ,AvelumabmarkedlyenhancesNK-celllysisrelativetoisotypecontrolinthefollowingcelllines:JHC7(7.56-fold;P=0.001),UM-Chor1(7.34-fold;P<0.001),U-CH2(2.6fold;

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