PfDHODH-IN-1-DataSheet-MedChemExpress

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摘要:Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemExpress.cnPfDHODH-IN-1Cat.No.:HY-135648CASNo.:183945-55-3分⼦式:C₁₄H₁₁F₃N₂O₂分⼦量:296.24作⽤靶点:Parasite;LactateDehydrogenase;DNA/RNASynthesis作⽤通路:Anti-infection;MetabolicEnzyme/Protease;CellCycle/DNADamage储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.BIOLOGICALACTIVITY⽣物活性PfDHODH-IN-1是⼀种Leflunomide活性代谢物的类似物。PfDHODH-IN-1是⼀种恶性疟原⾍⼆氢乳清酸脱氢酶(PfDHODH)抑制剂。PfDHODH-IN-1具有抗疟疾活性。REFERENCES[1].LiSL,etal.3D-QSARstudiesonaseriesofdihydroorotatedehydrogenaseinhibitors:analoguesoftheactivemetaboliteofleflunomide.IntJMolSci.2011;12(5):2982-93.[2].HouX,etal.QSARstudyontheantimalarialactivityofPlasmodiumfalciparumdihydro

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