CA-4948-DataSheet-MedChemExpress
摘要:Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemExpress.cnCA-4948Cat.No.:HY-135317CASNo.:1801344-14-8分⼦式:C₂₄H₂₅N₇O₅分⼦量:491.5作⽤靶点:IRAK作⽤通路:Immunology/Inflammation;ProteinTyrosineKinase/RTK储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.BIOLOGICALACTIVITY⽣物活性CA-4948是⼀种有效的、有⼝服活性的、选择性IRAK4激酶抑制剂，IC50[1]。IC50&TargetIRAK450nM(IC50)体内研究CA-4948isaselectiveandpotentIRAK4kinaseinhibitorwithinvivoactivityinaTLR4-inducedcytokinereleasemodel.CA-4948exhibitsfavorabledrugmetabolismandpharmacokinetic(DMPK)properties,oralbioavailability,andiswelltoleratedinmice.Moreover,CA-4948exhibitsdose-dependentefficacyinactivatedB-cell(ABC)-DLBCLMYD88-L265Pxenografttumormo
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