BCL6-IN-8c-DataSheet-MedChemExpress

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摘要:Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemExpress.cnBCL6-IN-8cCat.No.:HY-119402CASNo.:2130878-25-8分⼦式:C₂₀H₂₀ClN₃O₅分⼦量:417.84作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.BIOLOGICALACTIVITY⽣物活性BCL6-IN-8c是⼀种有效的⼝服活性B细胞淋巴瘤6(BCL6)-共抑制因⼦相互作⽤抑制剂，在⽆细胞酶联免疫吸附试验中，其IC50为0.10µM。IC50&TargetIC50:0.10µM(B-celllymphoma6(BCL6)-corepressorinteraction)[1]体外研究BCL6-IN-8c(Compound8c)alsoexhibitsgoodcellularPPIinhibitoryactivityinthesubmicromolarrange(M2HIC50=0.72µM).BCL6-IN-8cdoesnotexhibitsignificantcytotoxicityevenat30µM[1].体内研究ThepharmacokineticprofileofBCL6-IN-8c(Compound8c)isevaluatedbyamousecassette-dosingstudy(0.1mg/kgiv;1mg/kgpo

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