Lp-PLA2-IN-3-DataSheet-MedChemExpress

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摘要:Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemExpress.cnLp-PLA2-IN-3Cat.No.:HY-133149CASNo.:2196245-16-4分⼦式:C₂₀H₁₃ClF₃N₃O₃S分⼦量:467.85作⽤靶点:Phospholipase作⽤通路:MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.BIOLOGICALACTIVITY⽣物活性Lp-PLA2-IN-3是⼀种有效的、⼝服的脂蛋⽩相关磷脂酶A2(Lp-PLA2)抑制剂，对重组⼈Lp-PLA2(Lp-PLA2)的IC50为14nM。体内研究Lp-PLA2-IN-3(3mg/kg;p.o.)treatmentshowstheCmax,AUC0-24h,t1/2andFwere0.27μg/mL,3.4μgh/mL,7.7hoursand35.5%,respectively[1].Lp-PLA2-IN-3(1mg/kg;i.v.)treatmentshowstheCL,Vss,andt1/2were3.1mL/min/kg,0.3L/kg,4hours,respectively[1].AnimalModel:MaleSprague−Dawley(SD)rats(180-220g)[1]Dosage:3mg/kgAdministration:p.o.(Pharmacoki

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