Pasireotide-ditrifluoroacetate-SOM230-ditrifluoroacetate-DataSheet-MedChemExpress
摘要:Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemExpress.cnPasireotideditrifluoroacetateCat.No.:HY-79135Synonyms:SOM230ditrifluoroacetate;PasireotideTFAsalt分⼦式:C₆₂H₆₈F₆N₁₀O₁₃分⼦量:1275.25作⽤靶点:SomatostatinReceptor作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:PowderInsolvent-20°C3years4°C2years-80°C6months-20°C1monthBIOLOGICALACTIVITY⽣物活性Pasireotideditrifluoroacetate是⼀种稳定的环六肽⽣长激素抑制素模拟物，与⼈somatostatinreceptor具有很⾼的亲和性，包括sst1/2/3/4/5，pKi值分别为8.2/9.0/9.1/<7.0/9.9。IC50&TargetpKi:8.2(sst1),9.0(sst2),9.1(sst3),<7.0(sst4),9.9(sst5)体外研究Pasireotideeffectivelyinhibitsthegrowthhormonereleasinghormone(GHRH)inducedgrowthhormone(GH)releaseinprimaryculturesofratpituitarycellswithanIC50
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