GR-159897-DataSheet-MedChemExpress
摘要:•GR159897InhibitorsProductData SheetAgonistsHY-107691CASNo.:158848-32-9MolecularFormula:C₂₃H₂₇FN₂O₂SMolecularWeight:414.54Target:NeurokininReceptorPathway:GPCR/GProtein;NeuronalSignalingStorage:PleasestoretheproductundertherecommendedconditionsintheCOA.•Cat.No.:ScreeningLibrariesBIOLOGICALACTIVITYDescriptionGR159897isahighlypotent,selective,competitive,brain-penetratednon-peptideantagonistattachykininNK2receptors,inhibitsbindingof[3H]GR100679tohNK2-CHOcellsandratcolonmembraneswithpKisof9.51and10,respectively.Antagonizesbronchoconstriction,withanxiolytic-likeactivity[1].IC₅₀&TargetNK2hNK210(pKi,Ratcolon9.51(pKi,CHOcell)membrane)REFERENCES[1]. BeresfordIJ,etal.GR159897,apotentnon-p
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